ΕΡΕΥΝΗΤΙΚΗ ΟΜΑΔΑ 4
Τίτλος: «Μελέτη Βιοδραστικών Φυσικών Ενώσεων με Φαρμακολογικό Ενδιαφέρον σε Παθοφυσιολογικές Καταστάσεις που Συνδέονται με Αγγειογένεση και Φλεγμονή»
Υπεύθυνος: Λουτράρη Ελένη, Μοριακή Βιολόγος PhD
Άμεσοι Επιστημονικοί Συνεργάτες:
Μιχαηλίδου Μαίρη, MSc, PhD, μεταδιδακτορική ερευνήτρια
Ιωάννα Νάκα, προπτυχιακή φοιτήτρια Σχολής Χημικών Μηχανικών ΕΜΠ σε διπλωματική ερευνητική εργασία
Ενδεικτικές Δημοσιεύσεις
Loutrari, Η., Magkouta, S., Papapetropoulos, A. and Roussos, C. (2011) Mastic Oil Inhibits the Metastatic Phenotype of Mouse Lung Adenocarcinoma Cells. Cancers, 3, 789-801
http://www.ncbi.nlm.nih.gov/pubmed/24212641
Theodossiou, E., Loutrari, H., Stamatis, H. Roussos C, Kolisis FN. (2011), Biocatalytic synthesis and antitumor activities of novel silybin-acylated derivatives with dicatboxylic acids. N Biotechnol. 28(4):342-8
http://www.ncbi.nlm.nih.gov/pubmed/21320648
Morbidelli, L., Pyriochou, A., Filippi, S., Vassiliades, Y., Roussos, C., Loutrari, H., Giannis, A., Stössel, A., Ziche, M. and Papapetropoulos, A. (2010). The soluble guanylyl cyclase inhibitor NS-2028 reduces vascular endothelial growth factor-induced angiogenesis and permeability. Am J Physiol Regul Integr Comp Physiol., 298(3):R824-32.
http://www.ncbi.nlm.nih.gov/pubmed/20032260
Moulos, P. Papadodima, O., Chatziioannou, A., Loutrari, H., Roussos C and Kolisis, F.N. (2009). A transcriptomic computational analysis of mastic oil-treated Lewis lung carcinomas reveals molecular mechanisms targeting tumor cell growth and survival BMC Med Genomics, 2:68.
http://www.ncbi.nlm.nih.gov/pubmed/20003503
Magkouta, S., Stathopoulos, G.T., Psallidas, I., Papapetropoulos, A., Kolisis, F.N., Roussos, C. and Loutrari, H. (2009). Protective effects of mastic oil from Pistacia lentiscus variation chia against experimental growth of Lewis Lung Carcinoma. Nutrition & Cancer, 61(5): 640-648
http://www.ncbi.nlm.nih.gov/pubmed/19838938
Theodossiou, E., Katsoura, M.H., Loutrari, H., Purchartova , K., Kren, V., Kolisis, F.N. and Stamatis, H. (2009). Enzymatic preparation of acylated derivatives of silybin in organic and ionic liquids media and evaluation of their anti-tumor proliferative activity. Biocatalysis and Biotransformations, 27: 161 – 169
http://dx.doi.org/10.1080/10242420902937777
Xanthakis, E., Magkouta, S., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis, F.N. (2009). Enzymatic synthesis of perillyl alcohol derivatives and investigation of their antiproliferative activity. Biocatalysis and Biotransformation, 27: 170– 178.
http://dx.doi.org/10.1080/10242420902811089
Xanthakis, E., Theodossiou, E., Stamatis, H., Magkouta, S., Loutrari, H., Roussos, C. and Kolisis, F.N. (2009). Biotransformations of natural compounds: Structural and functional diversity of novel derivatives. Pure and Applied Chemistry, 82:1-16
http://dx.doi.org/10.1016/j.jbiotec.2008.07.600
Stathopoulos, G.T., Moschos, C., Loutrari, H., Kollintza, A., Psallidas, I., Karabela, S., Magkouta, S., Zhou, Z., Papiris, S.A., Roussos, C. and Kalomenidis, I. (2008). Zoledronic acid is effective against experimental malignant pleural effusion. American Journal of Respiratory and Critical Care Medicine, 178:50-59
www.ncbi.nlm.nih.gov/pubmed/18388351
Loutrari, Η., Magkouta, S., Pyriochou, A., Koika, V., Kolisis, F.N., Papapetropoulos, A. and Roussos, C. (2006). Mastic oil from Pistacia lentiscus var. chia inhibits growth and survival of human K562 leukemia cells and attenuates angiogenesis. Nutrition & Cancer. 55:86-93.
www.ncbi.nlm.nih.gov/pubmed/16965245
Mellou, F., Loutrari, H., Stamatis, H., Roussos, C. and Kolisis F.N. (2006). Enzymatic esterification of flavonoids with unsaturated fatty acids: Effect of the novel esters on Vascular Endothelial Growth Factor release from K562 cells. Process Biochemistry.41:2029-2034
http://dx.doi.org/10.1016/j.procbio.2006.05.002
Κotanidou A., Loutrari H., Papadomichelakis E., Glynos K., Magkou C., Armaganidis A., Papapetropoulos A., Roussos C. and Orfanos S.E. (2006). Inhaled activated protein C attenuates lung injury induced by endotoxin in mice. Vascular Pharmacology, 45: 134-140
http://www.ncbi.nlm.nih.gov/pubmed/16959545
Loutrari, H., Hatziapostolou, M., Skouridou, V., Papadimitriou, E., Roussos, C., Kolisis, F.N. and Papapetropoulos, A. (2004) Perillyl alcohol is an angiogenesis inhibitor. J Pharmacol Exp Ther. 311:568-75.
